Mutant p53 Disrupts Role of ShcA Protein in Balancing Smad Protein-dependent and -independent Signaling Activity of Transforming Growth Factor-β (TGF-β)

Biomarkers are lacking for identifying the switch of transforming growth factor-β (TGF-β) from tumor-suppressing to tumor-promoting. Mutated p53 (mp53) has been suggested to switch TGF-β to a tumor promoter. However, we found that mp53 does not always promote the oncogenic role of TGF-β. Here, we sh...

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Autores principales: Lin, Shu, Yu, Lan, Yang, Junhua, Liu, Zhao, Karia, Bijal, Bishop, Alexander J. R., Jackson, James, Lozano, Guillermina, Copland, John A., Mu, Xiaoxin, Sun, Beicheng, Sun, Lu-Zhe
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243540/
https://ncbi.nlm.nih.gov/pubmed/22039050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265397
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