Molecular Dissection of Cl(−)-selective Cys-loop Receptor Points to Components That Are Dispensable or Essential for Channel Activity

Cys-loop receptors are pentameric ligand-gated ion channels (pLGICs) that bind neurotransmitters to open an intrinsic transmembrane ion channel pore. The recent crystal structure of a prokaryotic pLGIC from the cyanobacterium Gloeobacter violaceus (GLIC) revealed that it naturally lacks an N-termina...

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Autores principales: Bar-Lev, Dekel D., Degani-Katzav, Nurit, Perelman, Alexander, Paas, Yoav
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Molecular Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243536/
https://ncbi.nlm.nih.gov/pubmed/21987577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.282715
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