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The nuclear receptor constitutive active/androstane receptor (CAR) arrests DNA-damaged human hepatocellular carcinoma Huh7 cells at the G2/M phase

Here we have demonstrated that xenobiotic activation of the nuclear receptor CAR (NR1I3) can result in arresting DNA-damaged human hepatocellular carcinoma Huh7 cells at the G2/M phase. Huh7 cells over-expressing CAR were either treated with DMSO, the CAR activator TCPOBOP, or repressor androstenol;...

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Autors principals: Kamino, Hiroki, Negishi, Masahiko
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242902/
https://ncbi.nlm.nih.gov/pubmed/21557330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20783
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