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A framework to select clinically relevant cancer cell lines for investigation by establishing their molecular similarity with primary human cancers

Experimental work using human cancer cell lines often does not translate to the clinic. We posit this is because some cells undergo changes in vitro that no longer make them representative of human tumors. Here we describe a novel alignment method named SRCCM (Spearman’s Rank Correlation Classificat...

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Autori principali: Dancik, Garrett M., Ru, Yuanbin, Owens, Charles, Theodorescu, Dan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242880/
https://ncbi.nlm.nih.gov/pubmed/22012889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2427
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