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A framework to select clinically relevant cancer cell lines for investigation by establishing their molecular similarity with primary human cancers
Experimental work using human cancer cell lines often does not translate to the clinic. We posit this is because some cells undergo changes in vitro that no longer make them representative of human tumors. Here we describe a novel alignment method named SRCCM (Spearman’s Rank Correlation Classificat...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3242880/ https://ncbi.nlm.nih.gov/pubmed/22012889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2427 |
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