Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3′-azido-2′,3′-dideoxypurine nucleosides

Microwave-assisted optimized transglycosylation reactions were used to prepare eleven modified l-3′-azido-2′,3′-dideoxypurine nucleosides. These l-nucleoside analogs were evaluated against HIV and hepatitis B virus. The l-3′-azido-2′,3′-dideoxypurines nucleosides were metabolized to nucleoside 5′-tr...

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Detalhes bibliográficos
Main Authors: Zhang, Hong-wang, Detorio, Mervi, Herman, Brian D., Solomon, Sarah, Bassit, Leda, Nettles, James H., Obikhod, Aleksandr, Tao, Si-jia, Mellors, John W., Sluis-Cremer, Nicolas, Coats, Steven J., Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242641/
https://ncbi.nlm.nih.gov/pubmed/21700368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.05.051
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