Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma

BACKGROUND: Upregulation of PIM kinase expression has been reported in many malignancies, suggesting that inhibition of PIM kinase activity may be an attractive therapeutic strategy. We hypothesised that inhibition of PIM kinase activity with SGI-1776, a novel small molecule inhibitor of PIM kinase...

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Detalhes bibliográficos
Main Authors: Mahalingam, D, Espitia, C M, Medina, E C, Esquivel, J A, Kelly, K R, Bearss, D, Choy, G, Taverna, P, Carew, J S, Giles, F J, Nawrocki, S T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242528/
https://ncbi.nlm.nih.gov/pubmed/22015557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.426
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