Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma

BACKGROUND: Upregulation of PIM kinase expression has been reported in many malignancies, suggesting that inhibition of PIM kinase activity may be an attractive therapeutic strategy. We hypothesised that inhibition of PIM kinase activity with SGI-1776, a novel small molecule inhibitor of PIM kinase...

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Bibliografiske detaljer
Main Authors:	Mahalingam, D, Espitia, C M, Medina, E C, Esquivel, J A, Kelly, K R, Bearss, D, Choy, G, Taverna, P, Carew, J S, Giles, F J, Nawrocki, S T
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2011
Fag:	Translational Therapeutics
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3242528/ https://ncbi.nlm.nih.gov/pubmed/22015557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.426
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Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma

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