The opposing transcriptional functions of Sin3A and c-Myc are required to maintain tissue homeostasis

How the proto-oncogene c-Myc balances the processes of stem cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc’s transcriptional roles at the Epidermal Differentiation Complex (EDC) a locus essential for skin maturation. Binding of c-Myc can s...

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Hauptverfasser: Nascimento, Elisabete M., Cox, Claire L., MacArthur, Stewart, Hussain, Shobbir, Trotter, Matthew, Blanco, Sandra, Suraj, Menon, Nichols, Jennifer, Kübler, Bernd, Benitah, Salvador Aznar, Hendrich, Brian, Odom, Duncan T., Frye, Michaela
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242072/
https://ncbi.nlm.nih.gov/pubmed/22101514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2385
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