The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin

Setd8/PR-Set7/KMT5a-dependent mono-methylation of histone H4 at lysine 20 is essential for mitosis of cultured cells; yet, the functional roles of Setd8 in complex mammalian tissues are unknown. We use skin as a model system to explore how Setd8 may regulate cell division in vivo. Deletion of Setd8...

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Detaylı Bibliyografya
Asıl Yazarlar: Driskell, Iwona, Oda, Hisanobu, Blanco, Sandra, Nascimento, Elisabete, Humphreys, Peter, Frye, Michaela
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273381/
https://ncbi.nlm.nih.gov/pubmed/22117221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.421
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