Tight Regulation of Memory CD8 T Cells Limits Their Effectiveness during Sustained High Viral Load

To design successful vaccines for chronic diseases, an understanding of memory CD8(+) T cell responses to persistent antigen re-stimulation is critical. However, most studies comparing memory and naïve cell responses have only been performed in rapidly cleared acute infections. Herein, by comparing...

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Hlavní autoři: West, Erin E., Youngblood, Ben, Tan, Wendy G., Jin, Hyun-Tak, Araki, Koichi, Alexe, Gabriela, Konieczny, Bogumila T., Calpe, Silvia, Freeman, Gordon J., Terhorst, Cox, Haining, W. Nicholas, Ahmed, Rafi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241982/
https://ncbi.nlm.nih.gov/pubmed/21856186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.05.017
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