Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction

The Diels-Alder reaction is a cornerstone in organic synthesis, forming two carbon-carbon bonds and up to four new stereogenic centers in one step. No naturally occurring enzymes have been shown to catalyze bimolecular Diels-Alder reactions. We describe the de novo computational design and experimen...

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Detalhes bibliográficos
Main Authors: Siegel, Justin B., Zanghellini, Alexandre, Lovick, Helena M., Kiss, Gert, Lambert, Abigail R., St.Clair, Jennifer L., Gallaher, Jasmine L., Hilvert, Donald, Gelb, Michael H., Stoddard, Barry L., Houk, Kendall N., Michael, Forrest E., Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241958/
https://ncbi.nlm.nih.gov/pubmed/20647463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1190239
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