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A Neutral Diphosphate Mimic Crosslinks the Active Site of Human O-GlcNAc Transferase
Glycosyltransferases (Gtfs) catalyze the formation of a diverse array of glycoconjugates. Small molecule inhibitors to manipulate Gtf activity in cells have long been sought as tools to understand Gtf function. Success has been limited due to challenges in designing inhibitors that mimic the negativ...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3241908/ https://ncbi.nlm.nih.gov/pubmed/22082911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.711 |
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