AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice

Brain inflammation is a double-edged sword: it is required for brain repair in acute damage, whereas chronic inflammation and autoimmune disorders are neuropathogenic. Certain pro-inflammatory cytokines and chemokines are closely related to cognitive dysfunction and neurodegeneration. Representative...

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Autores principales: Kiyota, Tomomi, Ingraham, Kaitlin L., Swan, Russell J., Jacobsen, Michael T., Andrews, Scott J., Ikezu, Tsuneya
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241853/
https://ncbi.nlm.nih.gov/pubmed/21918553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.126
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