AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, β-amyloidosis, and Learning Impairment of APP/PS1 Mice

Accumulation of aggregated amyloid-β (Aβ) peptide was studied as an initial step for Alzheimer's disease (AD) pathogenesis. Following amyloid plaque formation, reactive microglia and astrocytes accumulate around plaques and cause neuroinflammation. Here brain chemokines play a major role for th...

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Bibliografiske detaljer
Main Authors: Kiyota, Tomomi, Yamamoto, Masaru, Schroder, Bryce, Jacobsen, Michael T, Swan, Russell J, Lambert, Mary P, Klein, William L, Gendelman, Howard E, Ransohoff, Richard M, Ikezu, Tsuneya
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2009
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709991/
https://ncbi.nlm.nih.gov/pubmed/19277012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.44
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