Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells

BACKGROUND: The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, results with N-terminal inhibitors from initial clinical trials have been disappoi...

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Autors principals: Eskew, Jeffery D, Sadikot, Takrima, Morales, Pedro, Duren, Alicia, Dunwiddie, Irene, Swink, Megan, Zhang, Xiaoying, Hembruff, Stacey, Donnelly, Alison, Rajewski, Roger A, Blagg, Brian SJ, Manjarrez, Jacob R, Matts, Robert L, Holzbeierlein, Jeffrey M, Vielhauer, George A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240935/
https://ncbi.nlm.nih.gov/pubmed/22039910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-468
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