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The hERG channel is dependent upon the Hsp90α isoform for maturation and trafficking
Heat shock protein 90 (Hsp90) has emerged as a promising therapeutic target for the treatment of cancer. Several Hsp90 inhibitors have entered clinical trials. However, some toxicological detriments have arisen, such as cardiotoxicity resulting from hERG inhibition following the administration of Hs...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557513/ https://ncbi.nlm.nih.gov/pubmed/22554505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300138n |
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