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The hERG channel is dependent upon the Hsp90α isoform for maturation and trafficking

Heat shock protein 90 (Hsp90) has emerged as a promising therapeutic target for the treatment of cancer. Several Hsp90 inhibitors have entered clinical trials. However, some toxicological detriments have arisen, such as cardiotoxicity resulting from hERG inhibition following the administration of Hs...

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Detalhes bibliográficos
Main Authors: Peterson, Laura B., Eskew, Jeffrey D., Vielhauer, George A., Blagg, Brian S. J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557513/
https://ncbi.nlm.nih.gov/pubmed/22554505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300138n
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