Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence

Vaccinia virus (VACV) protein N1 is an intracellular virulence factor and belongs to a family of VACV B-cell lymphoma (Bcl)-2-like proteins whose members inhibit apoptosis or activation of pro-inflammatory transcription factors, such as interferon (IFN) regulatory factor-3 (IRF-3) and nuclear factor...

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Main Authors: Maluquer de Motes, Carlos, Cooray, Samantha, Ren, Hongwei, Almeida, Gabriel M. F., McGourty, Kieran, Bahar, Mohammad W., Stuart, David I., Grimes, Jonathan M., Graham, Stephen C., Smith, Geoffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240604/
https://ncbi.nlm.nih.gov/pubmed/22194685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002430
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