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Predictability of Evolutionary Trajectories in Fitness Landscapes

Experimental studies on enzyme evolution show that only a small fraction of all possible mutation trajectories are accessible to evolution. However, these experiments deal with individual enzymes and explore a tiny part of the fitness landscape. We report an exhaustive analysis of fitness landscapes...

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Bibliografske podrobnosti
Main Authors: Lobkovsky, Alexander E., Wolf, Yuri I., Koonin, Eugene V.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240586/
https://ncbi.nlm.nih.gov/pubmed/22194675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002302
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