Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes

INTRODUCTION: Cartilage degeneration driven by catabolic stimuli is a critical pathophysiological process in osteoarthritis (OA). We have defined fibroblast growth factor 2 (FGF-2) as a degenerative mediator in adult human articular chondrocytes. Biological effects mediated by FGF-2 include inhibiti...

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Main Authors: Yan, Dongyao, Chen, Di, Cool, Simon M, van Wijnen, Andre J, Mikecz, Katalin, Murphy, Gillian, Im, Hee-Jeong
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3239372/
https://ncbi.nlm.nih.gov/pubmed/21835001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3441
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