Mutations of the ras gene product p21 that abolish guanine nucleotide binding.

We have constructed several point mutations affecting the GTP-binding site of p21, the ras-encoded protein. Both lysine (116K) and tyrosine (116Y) mutations of asparagine-116, which, by analogy with the crystal structure of elongation factor Tu (EF-Tu), has critical interactions with the guanine bas...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Clanton, D J, Hattori, S, Shih, T Y
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1986
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323893/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3014531/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.14.5076
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