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Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

H2O2, in concentrations achieved in the proximity of stimulated leukocytes, induces injury and lysis of target cells. This may be an important aspect of inflammatory injury of tissues. Cell lysis in two target cells, the murine macrophage-like tumor cell line P388D1 and human peripheral lymphocytes,...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Schraufstatter, I U, Hyslop, P A, Hinshaw, D B, Spragg, R G, Sklar, L A, Cochrane, C G
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1986
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323853/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2941760/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.13.4908
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