Recruitment of cellular prion protein to mitochondrial raft-like microdomains contributes to apoptosis execution

We examined the possibility that cellular prion protein (PrP(C)) plays a role in the receptor-mediated apoptotic pathway. We first found that CD95/Fas triggering induced a redistribution of PrP(C) to the mitochondria of T lymphoblastoid CEM cells via a mechanism that brings into play microtubular ne...

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Main Authors: Mattei, Vincenzo, Matarrese, Paola, Garofalo, Tina, Tinari, Antonella, Gambardella, Lucrezia, Ciarlo, Laura, Manganelli, Valeria, Tasciotti, Vincenzo, Misasi, Roberta, Malorni, Walter, Sorice, Maurizio
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2011
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237627/
https://ncbi.nlm.nih.gov/pubmed/22031292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-04-0348
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