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Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy
BACKGROUND: Cellular therapies could play a role in cancer treatment and regenerative medicine if it were possible to quickly eliminate the infused cells in case of adverse events. We devised an inducible T-cell safety switch that is based on the fusion of human caspase 9 to a modified human FK-bind...
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| Autori principali: | , , , , , , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3236370/ https://ncbi.nlm.nih.gov/pubmed/22047558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1106152 |
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