Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

BACKGROUND: Cellular therapies could play a role in cancer treatment and regenerative medicine if it were possible to quickly eliminate the infused cells in case of adverse events. We devised an inducible T-cell safety switch that is based on the fusion of human caspase 9 to a modified human FK-bind...

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Autors principals: Di Stasi, Antonio, Tey, Siok-Keen, Dotti, Gianpietro, Fujita, Yuriko, Kennedy-Nasser, Alana, Martinez, Caridad, Straathof, Karin, Liu, Enli, Durett, April G., Grilley, Bambi, Liu, Hao, Cruz, Conrad R., Savoldo, Barbara, Gee, Adrian P., Schindler, John, Krance, Robert A., Heslop, Helen E., Spencer, David M., Rooney, Cliona M., Brenner, Malcolm K.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236370/
https://ncbi.nlm.nih.gov/pubmed/22047558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1106152
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