Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10

INTRODUCTION: SNPs rs2981582 and rs2981578, located in a linkage disequilibrium block (LD block) within intron 2 of the fibroblast growth factor receptor 2 gene (FGFR2), are associated with a mildly increased breast cancer risk. Allele-specific regulation of FGFR2 mRNA expression has been reported p...

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Hlavní autoři: Huijts, Petra EA, van Dongen, Minka, de Goeij, Moniek CM, van Moolenbroek, Adrian J, Blanken, Freek, Vreeswijk, Maaike PG, de Kruijf, Esther M, Mesker, Wilma E, van Zwet, Erik W, Tollenaar, Rob AEM, Smit, Vincent THBM, van Asperen, Christi J, Devilee, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236336/
https://ncbi.nlm.nih.gov/pubmed/21767389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2917
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