Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10

INTRODUCTION: SNPs rs2981582 and rs2981578, located in a linkage disequilibrium block (LD block) within intron 2 of the fibroblast growth factor receptor 2 gene (FGFR2), are associated with a mildly increased breast cancer risk. Allele-specific regulation of FGFR2 mRNA expression has been reported p...

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Détails bibliographiques
Auteurs principaux: Huijts, Petra EA, van Dongen, Minka, de Goeij, Moniek CM, van Moolenbroek, Adrian J, Blanken, Freek, Vreeswijk, Maaike PG, de Kruijf, Esther M, Mesker, Wilma E, van Zwet, Erik W, Tollenaar, Rob AEM, Smit, Vincent THBM, van Asperen, Christi J, Devilee, Peter
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236336/
https://ncbi.nlm.nih.gov/pubmed/21767389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2917
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