Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation.

The down-regulation and internalization of the epidermal growth factor (EGF) receptors induced by two separate anti-EGF monoclonal antibodies (mAbs), IgG1 mAb-225 and -455, and by EGF was examined. mAb-225 competitively inhibits EGF binding and it is internalized to an extent comparable to EGF. The...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Sunada, H, Magun, B E, Mendelsohn, J, MacLeod, C L
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1986
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323616/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2424012/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.11.3825
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