Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation.

The down-regulation and internalization of the epidermal growth factor (EGF) receptors induced by two separate anti-EGF monoclonal antibodies (mAbs), IgG1 mAb-225 and -455, and by EGF was examined. mAb-225 competitively inhibits EGF binding and it is internalized to an extent comparable to EGF. The...

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Bibliografske podrobnosti
Main Authors: Sunada, H, Magun, B E, Mendelsohn, J, MacLeod, C L
Format: Artigo
Jezik:Inglês
Izdano: 1986
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC323616/
https://ncbi.nlm.nih.gov/pubmed/2424012
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