Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation.
The down-regulation and internalization of the epidermal growth factor (EGF) receptors induced by two separate anti-EGF monoclonal antibodies (mAbs), IgG1 mAb-225 and -455, and by EGF was examined. mAb-225 competitively inhibits EGF binding and it is internalized to an extent comparable to EGF. The...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
1986
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323616/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2424012/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.11.3825 |
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