TNFα facilitates clonal expansion of JAK2(V617F) positive cells in myeloproliferative neoplasms

Proinflammatory cytokines such as TNFα are elevated in patients with myeloproliferative neoplasms (MPN), but their contribution to disease pathogenesis is unknown. Here we reveal a central role for TNFα in promoting clonal dominance of JAK2(V617F) expressing cells in MPN. We show that JAK2(V617F) ki...

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Библиографические подробности
Главные авторы: Fleischman, Angela G., Aichberger, Karl J., Luty, Samuel B., Bumm, Thomas G., Petersen, Curtis L., Doratotaj, Shirin, Vasudevan, Kavin B., LaTocha, Dorian H., Yang, Fei, Press, Richard D., Loriaux, Marc M., Pahl, Heike L., Silver, Richard T., Agarwal, Anupriya, O'Hare, Thomas, Druker, Brian J., Bagby, Grover C., Deininger, Michael W.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2011
Предметы:
Myeloid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236121/
https://ncbi.nlm.nih.gov/pubmed/21860020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-348144
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