Toward computer-aided site-directed mutagenesis of enzymes.
A preliminary attempt to simulate the observed effect of a site-directed mutagenesis of rat trypsin gives encouraging results. The calculations reproduce in a semiquantitative way the observed change in the activation barrier of the rate-limiting step of amide hydrolysis. This result, which did not...
Zapisane w:
| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
1986
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323612/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3520555/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.11.3806 |
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