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Determination of resveratrol and its sulfate and glucuronide metabolites in plasma by LC-MS/MS and their pharmacokinetics in dogs
An analytical approach for the determination of trans-resveratrol (3,5,4′-trihydroxy-trans-stilbene) and its glucuronide and sulfate conjugates in dog plasma by LC-MS/MS (without enzymatic hydrolysis of the conjugates) was validated to support pre-clinical toxicological and pharmacological studies....
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3235727/ https://ncbi.nlm.nih.gov/pubmed/22079044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2011.10.023 |
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