Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

The embryonic pyruvate kinase M2 (PKM2) isoform is highly expressed in human cancer. In contrast to the established role of PKM2 in aerobic glycolysis or the Warburg effect(1,2,3), its nonmetabolic functions remain elusive. Here we demonstrate that EGFR activation induces translocation of PKM2, but...

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Autori principali: Yang, Weiwei, Xia, Yan, Ji, Haitao, Zheng, Yanhua, Liang, Ji, Huang, Wenhua, Gao, Xiang, Aldape, Kenneth, Lu, Zhimin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235705/
https://ncbi.nlm.nih.gov/pubmed/22056988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10598
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