EGF-induced ERK activation promotes CK2-mediated disassociation of α-catenin from β-catenin and transactivation of β-catenin

Increased transcriptional activity of β-catenin resulting from Wnt/Wingless-dependent or - independent signaling has been detected in many types of human cancer, but the underlying mechanism of Wnt-independent regulation remains unclear. We demonstrate here that EGFR activation results in disruption...

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Hlavní autoři: Ji, Haitao, Wang, Ji, Nika, Heinz, Hawke, David, Keezer, Susan, Ge, Qingyuan, Fang, Bingliang, Fang, Xuexun, Litchfield, David W., Aldape, Kenneth, Lu, Zhimin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784926/
https://ncbi.nlm.nih.gov/pubmed/19941816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.034
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