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SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFβ
The transcriptional co-regulator SKI is a potent inhibitor of TGFβ-growth inhibitory signals. SKI binds to receptor-activated Smads in the nucleus, forming repressor complexes containing HDACs, mSin3, NCoR and other protein partners. Alternatively, SKI binds to activated Smads in the cytoplasm, prev...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3235508/ https://ncbi.nlm.nih.gov/pubmed/20404506 |
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