The phosphorylation of the Smad2/3 linker region by nemo-like kinase regulates TGF-β signaling

Smad2 and Smad3 (Smad2/3) are structurally similar proteins that primarily mediate the transforming growth factor-β (TGF-β) signaling responsible for driving cell proliferation, differentiation, and migration. The dynamics of the Smad2/3 phosphorylation provide the key mechanism for regulating the T...

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Udgivet i:J Biol Chem
Main Authors: Liang, Junbo, Zhou, Yanchi, Zhang, Ning, Wang, Dingding, Cheng, Xiaowen, Li, Kai, Huang, Rong, Lu, Yan, Wang, Hailong, Han, Deqiang, Wu, Wei, Han, Meng, Miao, Shiying, Wang, Linfang, Zhao, Hong, Song, Wei
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047224/
https://ncbi.nlm.nih.gov/pubmed/33676893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100512
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