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Diverging Mechanisms of Activation of Chemokine Receptors Revealed by Novel Chemokine Agonists
CXCL8/interleukin-8 is a pro-inflammatory chemokine that triggers pleiotropic responses, including inflammation, angiogenesis, wound healing and tumorigenesis. We engineered the first selective CXCR1 agonists on the basis of residue substitutions in the conserved ELR triad and CXC motif of CXCL8. Ou...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3235101/ https://ncbi.nlm.nih.gov/pubmed/22174759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027967 |
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