Diverging Mechanisms of Activation of Chemokine Receptors Revealed by Novel Chemokine Agonists

CXCL8/interleukin-8 is a pro-inflammatory chemokine that triggers pleiotropic responses, including inflammation, angiogenesis, wound healing and tumorigenesis. We engineered the first selective CXCR1 agonists on the basis of residue substitutions in the conserved ELR triad and CXC motif of CXCL8. Ou...

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Bibliografiska uppgifter
Huvudupphovsmän: Sarmiento, Jose, Shumate, Christie, Suetomi, Katsutoshi, Ravindran, Aishwarya, Villegas, León, Rajarathnam, Krishna, Navarro, Javier
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2011
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235101/
https://ncbi.nlm.nih.gov/pubmed/22174759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027967
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