The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): THREE-DIMENSIONAL STRUCTURE AND LOCALIZATION OF A CHANNEL GATE

Cystic fibrosis affects about 1 in 2500 live births and involves loss of transmembrane chloride flux due to a lack of a membrane protein channel termed the cystic fibrosis transmembrane conductance regulator (CFTR). We have studied CFTR structure by electron crystallography. The data were compared w...

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Autors principals: Rosenberg, Mark F., O'Ryan, Liam P., Hughes, Guy, Zhao, Zhefeng, Aleksandrov, Luba A., Riordan, John R., Ford, Robert C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234965/
https://ncbi.nlm.nih.gov/pubmed/21931164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292268
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