Identification of P-Rex1 as a Novel Rac1-Guanine Nucleotide Exchange Factor (GEF) That Promotes Actin Remodeling and GLUT4 Protein Trafficking in Adipocytes

Phosphoinositide 3-kinase (PI3K) signaling promotes the translocation of the glucose transporter, GLUT4, to the plasma membrane in insulin-sensitive tissues to facilitate glucose uptake. In adipocytes, insulin-stimulated reorganization of the actin cytoskeleton has been proposed to play a role in pr...

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Bibliografiske detaljer
Main Authors: Balamatsias, Demis, Kong, Anne M., Waters, Joanne E., Sriratana, Absorn, Gurung, Rajendra, Bailey, Charles G., Rasko, John E. J., Tiganis, Tony, Macaulay, S. Lance, Mitchell, Christina A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234845/
https://ncbi.nlm.nih.gov/pubmed/22002247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.306621
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