IDENTIFICATION OF THE Rac-GEF P-REX1 AS AN ESSENTIAL MEDIATOR OF ErbB SIGNALING IN BREAST CANCER

While the small GTPase Rac1 and its effectors are well-established mediators of mitogenic and motile signaling by tyrosine-kinase receptors and have been implicated in breast tumorigenesis, little is known regarding the exchange factors (Rac-GEFs) that mediate ErbB receptor responses. Here we identi...

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Autori principali: Sosa, Maria Soledad, Lopez-Haber, Cynthia, Yang, Chengfeng, Wang, Hongbin, Lemmon, Mark A., Busillo, John M., Luo, Jiansong, Benovic, Jeffrey L., Klein-Szanto, Andres, Yagi, Hiroshi, Gutkind, J. Silvio, Parsons, Ramon E., Kazanietz, Marcelo G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038344/
https://ncbi.nlm.nih.gov/pubmed/21172654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.11.029
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