Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation

INTRODUCTION: The Rac-GEF P-REX1 is a key mediator of ErbB signaling in breast cancer recently implicated in mammary tumorigenesis and metastatic dissemination. Although P-REX1 is essentially undetectable in normal human mammary epithelial tissue, this Rac-GEF is markedly upregulated in human breast...

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發表在:Breast Cancer Res
Main Authors: Barrio-Real, Laura, Benedetti, Lorena G, Engel, Nora, Tu, Yaping, Cho, Soonweng, Sukumar, Saraswati, Kazanietz, Marcelo G
格式: Artigo
語言:Inglês
出版: BioMed Central 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303123/
https://ncbi.nlm.nih.gov/pubmed/25248717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0441-7
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