Solution Structure of the State 1 Conformer of GTP-bound H-Ras Protein and Distinct Dynamic Properties between the State 1 and State 2 Conformers

Ras small GTPases undergo dynamic equilibrium of two interconverting conformations, state 1 and state 2, in the GTP-bound forms, where state 2 is recognized by effectors, whereas physiological functions of state 1 have been unknown. Limited information, such as static crystal structures and (31)P NM...

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Main Authors: Araki, Mitsugu, Shima, Fumi, Yoshikawa, Yoko, Muraoka, Shin, Ijiri, Yuichi, Nagahara, Yuka, Shirono, Tomoya, Kataoka, Tohru, Tamura, Atsuo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234787/
https://ncbi.nlm.nih.gov/pubmed/21930707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227074
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