In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras–effector interaction

Mutational activation of the Ras oncogene products (H-Ras, K-Ras, and N-Ras) is frequently observed in human cancers, making them promising anticancer drug targets. Nonetheless, no effective strategy has been available for the development of Ras inhibitors, partly owing to the absence of well-define...

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Detalhes bibliográficos
Main Authors: Shima, Fumi, Yoshikawa, Yoko, Ye, Min, Araki, Mitsugu, Matsumoto, Shigeyuki, Liao, Jingling, Hu, Lizhi, Sugimoto, Takeshi, Ijiri, Yuichi, Takeda, Azusa, Nishiyama, Yuko, Sato, Chie, Muraoka, Shin, Tamura, Atsuo, Osoda, Tsutomu, Tsuda, Ken-ichiro, Miyakawa, Tomoya, Fukunishi, Hiroaki, Shimada, Jiro, Kumasaka, Takashi, Yamamoto, Masaki, Kataoka, Tohru
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657810/
https://ncbi.nlm.nih.gov/pubmed/23630290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217730110
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