In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras–effector interaction

Mutational activation of the Ras oncogene products (H-Ras, K-Ras, and N-Ras) is frequently observed in human cancers, making them promising anticancer drug targets. Nonetheless, no effective strategy has been available for the development of Ras inhibitors, partly owing to the absence of well-define...

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Hauptverfasser: Shima, Fumi, Yoshikawa, Yoko, Ye, Min, Araki, Mitsugu, Matsumoto, Shigeyuki, Liao, Jingling, Hu, Lizhi, Sugimoto, Takeshi, Ijiri, Yuichi, Takeda, Azusa, Nishiyama, Yuko, Sato, Chie, Muraoka, Shin, Tamura, Atsuo, Osoda, Tsutomu, Tsuda, Ken-ichiro, Miyakawa, Tomoya, Fukunishi, Hiroaki, Shimada, Jiro, Kumasaka, Takashi, Yamamoto, Masaki, Kataoka, Tohru
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657810/
https://ncbi.nlm.nih.gov/pubmed/23630290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217730110
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