In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras–effector interaction

Mutational activation of the Ras oncogene products (H-Ras, K-Ras, and N-Ras) is frequently observed in human cancers, making them promising anticancer drug targets. Nonetheless, no effective strategy has been available for the development of Ras inhibitors, partly owing to the absence of well-define...

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Bibliografiset tiedot
Päätekijät: Shima, Fumi, Yoshikawa, Yoko, Ye, Min, Araki, Mitsugu, Matsumoto, Shigeyuki, Liao, Jingling, Hu, Lizhi, Sugimoto, Takeshi, Ijiri, Yuichi, Takeda, Azusa, Nishiyama, Yuko, Sato, Chie, Muraoka, Shin, Tamura, Atsuo, Osoda, Tsutomu, Tsuda, Ken-ichiro, Miyakawa, Tomoya, Fukunishi, Hiroaki, Shimada, Jiro, Kumasaka, Takashi, Yamamoto, Masaki, Kataoka, Tohru
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2013
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657810/
https://ncbi.nlm.nih.gov/pubmed/23630290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217730110
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