Critical Roles of Interactions among Switch I-preceding Residues and between Switch II and Its Neighboring α-Helix in Conformational Dynamics of the GTP-bound Ras Family Small GTPases

GTP-bound forms of Ras family small GTPases exhibit dynamic equilibrium between two interconverting conformations, “inactive” state 1 and “active” state 2. A great variation exists in their state distribution; H-Ras mainly adopts state 2, whereas M-Ras predominantly adopts state 1. Our previous stud...

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Détails bibliographiques
Auteurs principaux: Matsumoto, Kousuke, Shima, Fumi, Muraoka, Shin, Araki, Mitsugu, Hu, Lizhi, Ijiri, Yuichi, Hirai, Rina, Liao, Jingling, Yoshioka, Takashi, Kumasaka, Takashi, Yamamoto, Masaki, Tamura, Atsuo, Kataoka, Tohru
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083163/
https://ncbi.nlm.nih.gov/pubmed/21388959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204933
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