Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Second-phase insulin release requires the sustained mobilization of insulin granules from internal storage pools to the cell surface for fusion with the plasma membrane. However, the detailed mechanisms underlying this process remain largely unknown. GTP-loading of the small GTPase Cdc42 is the firs...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kepner, Erica M., Yoder, Stephanie M., Oh, Eunjin, Kalwat, Michael A., Wang, Zhanxiang, Quilliam, Lawrence A., Thurmond, Debbie C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2011
Pynciau:
Editorial Focus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233779/
https://ncbi.nlm.nih.gov/pubmed/21828338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00312.2011
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg