Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Second-phase insulin release requires the sustained mobilization of insulin granules from internal storage pools to the cell surface for fusion with the plasma membrane. However, the detailed mechanisms underlying this process remain largely unknown. GTP-loading of the small GTPase Cdc42 is the firs...

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Autores principales: Kepner, Erica M., Yoder, Stephanie M., Oh, Eunjin, Kalwat, Michael A., Wang, Zhanxiang, Quilliam, Lawrence A., Thurmond, Debbie C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2011
Materias:
Editorial Focus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233779/
https://ncbi.nlm.nih.gov/pubmed/21828338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00312.2011
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