Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Second-phase insulin release requires the sustained mobilization of insulin granules from internal storage pools to the cell surface for fusion with the plasma membrane. However, the detailed mechanisms underlying this process remain largely unknown. GTP-loading of the small GTPase Cdc42 is the firs...

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Bibliografiska uppgifter
Huvudupphovsmän: Kepner, Erica M., Yoder, Stephanie M., Oh, Eunjin, Kalwat, Michael A., Wang, Zhanxiang, Quilliam, Lawrence A., Thurmond, Debbie C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2011
Ämnen:
Editorial Focus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233779/
https://ncbi.nlm.nih.gov/pubmed/21828338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00312.2011
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