Trop-2 overexpression in poorly differentiated endometrial endometrioid adenocarcinoma: Implications for immunotherapy with hRS7, a humanized anti-Trop-2 monoclonal antibody

OBJECTIVE: We evaluated the expression of human trophoblast cell-surface marker (Trop-2) in endometrial endometrioid carcinoma (EEC) and the potential application of hRS7, a humanized monoclonal anti-Trop-2 antibody, as a therapeutic agent against poorly-differentiated EEC. METHODS: Trop-2 expressio...

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Autori principali: Bignotti, Eliana, Ravaggi, Antonella, Romani, Chiara, Falchetti, Marcella, Lonardi, Silvia, Facchetti, Fabio, Pecorelli, Sergio, Varughese, Joyce, Cocco, Emiliano, Bellone, Stefania, Schwartz, Peter E., Rutherford, Thomas J., Santin, Alessandro D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233648/
https://ncbi.nlm.nih.gov/pubmed/21892093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/IGC.0b013e318228f6da
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