Uterine Serous Papillary Carcinomas overexpress human trophoblast-cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized anti-Trop-2 monoclonal antibody

BACKGROUND: Uterine Serous Papillary Carcinoma (USPC), is an aggressive and chemotherapy resistant variant of endometrial cancer. We evaluated the expression of human –trophoblast-cell-surface-marker (Trop-2) and the potential of hRS7, a humanized anti-Trop-2 monoclonal antibody, as a novel therapeu...

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Autors principals: Varughese, Joyce, Cocco, Emiliano, Bellone, Stefania, de Leon, Maria, Bellone, Marta, Todeschini, Paola, Schwartz, Peter E., Rutherford, Thomas J., Pecorelli, Sergio, Santin, Alessandro D.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128671/
https://ncbi.nlm.nih.gov/pubmed/21246534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.25891
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