High-grade, chemotherapy-resistant primary ovarian carcinoma cell lines overexpress human trophoblast cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized monoclonal anti-Trop-2 antibody

OBJECTIVE: We evaluated the expression of human trophoblast cell-surface marker (Trop-2) and the potential of hRS7, a humanized monoclonal anti-Trop-2 antibody, as a therapeutic agent against chemotherapy-resistant ovarian disease. METHODS: Trop-2 expression was evaluated by immunohistochemistry (IH...

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Detalhes bibliográficos
Main Authors: Varughese, Joyce, Cocco, Emiliano, Bellone, Stefania, Bellone, Marta, Todeschini, Paola, Carrara, Luisa, Schwartz, Peter E., Rutherford, Thomas J., Pecorelli, Sergio, Santin, Alessandro D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104081/
https://ncbi.nlm.nih.gov/pubmed/21453957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2011.03.002
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